Hirata Yuko, Zai Clement C, Nowrouzi Behdin, Shaikh Sajid A, Kennedy James L, Beitchman Joe H
aNeurogenetics Section bChild Psychiatry Section, Child, Youth, and Family Program, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
Psychiatr Genet. 2016 Feb;26(1):48-51. doi: 10.1097/YPG.0000000000000108.
This study examined the possible association between prolactin (PRL) system genes and callous-unemotional (CU) traits in childhood-onset aggression. Two markers for the PRL peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped. The participants were assessed on the CU subscale using five items from the Antisocial Process Screening Device. Genotype analysis showed nominally significant results with PRLR_rs187490 (uncorrected P=0.01), with the GG genotype associated with higher CU scores. This is the first paper to evaluate the relationship of PRL system genes with CU traits in childhood-onset aggression.
本研究探讨了催乳素（PRL）系统基因与儿童期起病的攻击行为中冷酷无情（CU）特质之间的可能关联。对PRL肽基因的两个标记和催乳素受体（PRLR）基因的三个标记进行了基因分型。使用反社会行为筛查工具中的五个项目对参与者的CU子量表进行评估。基因型分析显示，PRLR_rs187490具有名义上的显著结果（未校正P = 0.01），GG基因型与较高的CU得分相关。这是第一篇评估PRL系统基因与儿童期起病的攻击行为中CU特质之间关系的论文。
