通过细胞内递送提高非阳离子依赖性甘露糖6-磷酸受体抑制剂的疗效。
Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery.
作者信息
Agarwal Vipul, Toshniwal Priyanka, Smith Natalie E, Smith Nicole M, Li Binbin, Clemons Tristan D, Byrne Lindsay T, Kakulas Foteini, Wood Fiona M, Fear Mark, Corry Ben, Swaminathan Iyer K
机构信息
School of Chemistry and Biochemistry, The University of Western Australia, Crawley, Western Australia, Australia.
出版信息
Chem Commun (Camb). 2016 Jan 7;52(2):327-30. doi: 10.1039/c5cc06826f. Epub 2015 Oct 30.
PMID:26514404
Abstract
Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ1 mediated upregulation of profibrotic marker, collagen I.
摘要
M6P/IGFII受体抑制剂的细胞内递送在调节TGFβ1介导的促纤维化标志物I型胶原上调方面比细胞外抑制剂表现出更好的疗效。
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