幽门螺杆菌相关性胃炎患者中MDM2 SNP309的基因多态性
Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis.
作者信息
Tongtawee Taweesak, Dechsukhum Chavaboon, Leeanansaksiri Wilairat, Kaewpitoon Soraya, Kaewpitoon Natthawut, Loyd Ryan A, Matrakool Likit, Panpimanmas Sukij
机构信息
Department of Surgery, Suranaree University of Technology, Nakhon Rachasima, Thailand E-mail :
出版信息
Asian Pac J Cancer Prev. 2015;16(16):7049-52. doi: 10.7314/apjcp.2015.16.16.7049.
BACKGROUND
Helicobacter pylori plays an important role in gastric cancer, which has a relatively low inciduence in Thailand. MDM2 is a major negative regulator of p53, the key tumor suppressor involved in tumorigenesis of the majority of human cancers. Whether its expression might explain the relative lack of gastric cancer in Thailand was assessed here.
MATERIALS AND METHODS
This single-center study was conducted in the northeast region of Thailand. Gastric mucosa from 100 patients with Helicobacter pylori associated gastritis was analyzed for MDM2 SNP309 using real-time PCR hybridization (light-cycler) probes.
RESULTS
In the total 100 Helicobacter pylori associated gastritis cases the incidence of SNP 309 T/T homozygous was 78 % with SNP309 G/T heterozygous found in 19% and SNP309 G/G homozygous in 3%. The result show SNP 309 T/T and SNP 309 G/T to be rather common in the Thai population.
CONCLUSIONS
Our study indicates that the MDM2 SNP309 G/G homozygous genotype might be a risk factor for gastric cancer in Thailand and the fact that it is infrequent could explain to some extent the low incidence of gastric cancer in the Thai population.
背景
幽门螺杆菌在胃癌发生中起重要作用，而胃癌在泰国的发病率相对较低。MDM2是p53的主要负调控因子，p53是大多数人类癌症肿瘤发生过程中的关键肿瘤抑制因子。本文评估了MDM2的表达是否可以解释泰国胃癌相对较少的原因。
材料与方法
这项单中心研究在泰国东北部地区进行。采用实时PCR杂交（LightCycler）探针分析了100例幽门螺杆菌相关性胃炎患者的胃黏膜MDM2 SNP309情况。
结果
在总共100例幽门螺杆菌相关性胃炎病例中，SNP 309 T/T纯合子的发生率为78%，SNP309 G/T杂合子为19%，SNP309 G/G纯合子为3%。结果显示SNP 309 T/T和SNP 309 G/T在泰国人群中相当常见。
结论
我们的研究表明，MDM2 SNP309 G/G纯合基因型可能是泰国胃癌的一个危险因素，其罕见性在一定程度上可以解释泰国人群胃癌发病率较低的原因。
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