Gloger S, Grunhaus L, Gladic D, O'Ryan F, Cohen L, Codner S
Department of Psychiatry, University of Chile, Santiago.
J Clin Psychopharmacol. 1989 Feb;9(1):28-32.
Seventeen outpatients with panic anxiety and agoraphobia were treated with a low, flexible dose of clomipramine in an 8-week open trial. Panic attacks ceased completely in 13 patients and markedly decreased in the other four without additional therapeutic measures. Avoidance behavior disappeared in five of the seven agoraphobic patients. Overall mean dosage was 45 mg/day, with eight patients receiving clomipramine 25 mg or less. Higher doses were needed when agoraphobia was present. These results are discussed in conjunction with previous findings and lend support to serotonergic involvement in panic anxiety. Further double-blind studies are needed to confirm these results.
17名患有惊恐焦虑症和广场恐惧症的门诊患者在一项为期8周的开放试验中接受了低剂量、灵活调整的氯米帕明治疗。13名患者的惊恐发作完全停止，另外4名患者在未采取额外治疗措施的情况下发作明显减少。7名广场恐惧症患者中有5名的回避行为消失。总体平均剂量为45毫克/天，8名患者服用的氯米帕明剂量为25毫克或更低。存在广场恐惧症时需要更高剂量。这些结果结合先前的研究结果进行了讨论，并支持血清素能参与惊恐焦虑症的观点。需要进一步的双盲研究来证实这些结果。
