肌萎缩侧索硬化症：历史视角

Amyotrophic Lateral Sclerosis: A Historical Perspective.

作者信息

Katz Jonathan S, Dimachkie Mazen M, Barohn Richard J

机构信息

Department of Neurology, Forbes Norris MDA/ALS Center, California Pacific Medical Center, 2324 Sacramento Street, Suite 111, San Francisco, CA 94115, USA.

Department of Neurology, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Mail Stop 2012, Kansas City, KS 66160, USA.

出版信息

Neurol Clin. 2015 Nov;33(4):727-34. doi: 10.1016/j.ncl.2015.07.013.

DOI:10.1016/j.ncl.2015.07.013

PMID:26515617

Abstract

This article looks back in time to see where the foundational basis for the understanding of amyotrophic lateral sclerosis originated. This foundation was created primarily in France by Jean-Martin Charcot and his fellow countrymen and disciples, along with key contributions from early clinicians in England and Germany. The early work on amyotrophic lateral sclerosis provides a useful foundation for today's clinicians with respect to tying together genetic and biologic aspects of the disorder that have been discovered over the past few decades.

摘要

本文回顾历史，探寻对肌萎缩侧索硬化症理解的基础源自何处。这一基础主要由让 - 马丁·夏科及其法国同胞和弟子奠定，同时英国和德国的早期临床医生也做出了关键贡献。过去几十年中发现的肌萎缩侧索硬化症的遗传学和生物学方面，早期对其的研究为当今临床医生提供了一个有用的基础，将这些方面联系在一起。