愈创香醇：一种从波斯石蚕（Teucrium persicum Boiss.）中分离得到的新型愈创木烷倍半萜

Guaiasistanol: A new guaiane sesquiterpenoid from Teucrium persicum Boiss.

作者信息

Miri A, Sharifi-Rad J

机构信息

Zabol University of Medical Sciences Zabol Medicinal Plants Research Center Zabol Iran.

Zabol University of Medical Sciences Zabol Medicinal Plants Research Center Zabol Iran javad.sharifirad&commat;gmail.com.

出版信息

Cell Mol Biol (Noisy-le-grand). 2015 Oct 23;61(5):64-7.

PMID:26516112

Abstract

In this study, a new guaiane type skeleton sesquiterpenoid named guaiasistanol (6α, 10α-epoxy-4α-hydroxyguaiane) was isolated from chloroform part of the Teucrium persicum extract, also chrysothol. Spectroscopic means explained the structures. This compound was evaluated for inhibitory activity against acetylcholinesterase and it showed a moderate activity with 28% inhibition.

摘要

在本研究中，从波斯荆芥提取物的氯仿部分分离出一种新的愈创木烷型骨架倍半萜类化合物，命名为愈创木烷醇（6α, 10α-环氧-4α-羟基愈创木烷），还有金褐醇。通过光谱手段解析了其结构。对该化合物进行了乙酰胆碱酯酶抑制活性评估，结果显示其具有中等活性，抑制率为28%。