用于顽固性疼痛的神经轴（硬膜外和鞘内）阿片类药物。
Neuraxial (epidural and intrathecal) opioids for intractable pain.
作者信息
Farquhar-Smith Paul, Chapman Suzanne
机构信息
Royal Marsden NHS Foundation Trust, London, UK.
出版信息
Br J Pain. 2012 Feb;6(1):25-35. doi: 10.1177/2049463712439256.
Abstract
- Neuraxial opioids are considered for use in patients who have resistant intractable pain that fails to respond to other treatment options or pain that responds to analgesia but for which the doses required result in unacceptable side-effects. 2. Neuraxial opiods can be considered for both chronic non-malignant pain and chronic cancer-related pain. 3. Effectiveness in chronic non-malignant pain and cancer pain is exerted through the use of either single-agent drugs (opioids) or a combination of drugs: opioids, local anaesthetics and other drugs such as clonodine and ziconotide. 4. Complications of long-term continuous infusion therapy are related to the insertion process (haematoma), the mechanical device (both pump and catheter) and the long-term effects of the drugs. 5. Patients will require ongoing ambulatory monitoring and supportive care.
摘要
- 对于顽固性疼痛对其他治疗方法无效或对镇痛有反应但所需剂量会导致不可接受的副作用的患者，可考虑使用椎管内阿片类药物。2. 椎管内阿片类药物可用于慢性非恶性疼痛和慢性癌痛。3. 通过使用单药（阿片类药物）或联合用药（阿片类药物、局部麻醉药以及可乐定和齐考诺肽等其他药物）来发挥对慢性非恶性疼痛和癌痛的疗效。4. 长期持续输注治疗的并发症与置入过程（血肿）、机械装置（泵和导管）以及药物的长期影响有关。5. 患者需要持续的门诊监测和支持性护理。
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