White matter microstructure between the pre-SMA and the cingulum bundle is related to response conflict in healthy subjects.

INTRODUCTION

Response conflict involves selectively attending to relevant information and suppressing distracting, irrelevant information. The medial frontal cortex (MFC) is considered to be involved in response conflict. However, it remains unclear which white matter connectivity is associated with response conflict. This study aimed to delineate the neural connectivity of response conflict in healthy subjects and investigate the association between white matter microstructure and performance of a response conflict task.

METHOD

Twenty-eight healthy subjects underwent functional magnetic resonance imaging (fMRI) during the Flanker task and diffusion MRI. We identified the presupplementary motor area (pre-SMA) using fMRI. Furthermore, we delineated the white matter connectivity between the pre-SMA and the cingulum bundle (CB), which is located in the MFC, using probabilistic tractography. We calculated the mean diffusivity (MD), index of white matter microstructure, of this tract and evaluate the association between MD and performance of the Flanker task.

RESULT

The mean MD of this tract was significantly and positively associated with performance of the Flanker task.

CONCLUSION

The present study suggests the white matter connectivity between the pre-SMA and the CB is related to the response conflict in healthy subjects and finer white matter microstructure is associated with smaller response conflict.