Parker Rachael N, Grove Tijana Z
Department of Chemistry, Virginia Tech, Blacksburg, VA 24060, U.S.A.
Biochem Soc Trans. 2015 Oct;43(5):856-60. doi: 10.1042/BST20150085.
Advances in protein engineering tools, both computational and experimental, has afforded many new protein structures and functions. Here, we present a snapshot of repeat-protein engineering efforts towards new, versatile, alternative binding scaffolds for use in analytical sensors and as imaging agents. Analytical assays, sensors and imaging agents based on the direct binding of analyte are increasingly important for research and diagnostics in medicine, food safety, and national security.
蛋白质工程工具在计算和实验方面的进展已经带来了许多新的蛋白质结构和功能。在此，我们展示了重复蛋白工程为用于分析传感器和成像剂的新型、多功能、替代性结合支架所做努力的一个概况。基于分析物直接结合的分析测定、传感器和成像剂在医学、食品安全和国家安全的研究与诊断中变得越来越重要。
