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描述美沙酮和丁丙诺啡维持治疗患者的疼痛及相关应对策略。

Characterizing pain and associated coping strategies in methadone and buprenorphine-maintained patients.

作者信息

Dunn Kelly E, Finan Patrick H, Tompkins D Andrew, Fingerhood Michael, Strain Eric C

机构信息

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

出版信息

Drug Alcohol Depend. 2015 Dec 1;157:143-9. doi: 10.1016/j.drugalcdep.2015.10.018. Epub 2015 Oct 19.

Abstract

BACKGROUND

Chronic pain is common among patients receiving opioid maintenance treatment (OMT) for opioid use disorder. To aid development of treatment recommendations for coexisting pain and opioid use disorder, it is necessary to characterize pain treatment needs and assess whether needs differ as a function of OMT medication.

METHODS

A point-prevalence survey assessing pain and engagement in coping strategies was administered to 179 methadone and buprenorphine-maintained patients.

RESULTS

Forty-two percent of participants were categorized as having chronic pain. Methadone patients had greater severity of pain relative to buprenorphine patients, though both groups reported high levels of interference with daily activities, and participants with pain attended the emergency room more frequently relative to participants without pain. Only 2 coping strategies were being utilized by more than 50% of participants (over-the-counter medication, prayer).

CONCLUSIONS

Results indicate that pain among OMT patients is common, severe, and of significant impairment. Methadone patients reported greater severity pain, particularly worse pain in the past 24h, though interference from pain in daily activities did not vary as a function of OMT. Most participants with pain were utilizing few evidenced-based pain coping strategies. Increasing OMT patient access to additional pain treatment strategies is an opportunity for immediate intervention, and similarities across OMT type suggest interventions do not need to be customized to methadone vs. buprenorphine patients.

摘要

背景

在接受阿片类药物使用障碍阿片类维持治疗(OMT)的患者中,慢性疼痛很常见。为了帮助制定针对并存疼痛和阿片类药物使用障碍的治疗建议,有必要描述疼痛治疗需求,并评估需求是否因OMT药物而异。

方法

对179名接受美沙酮和丁丙诺啡维持治疗的患者进行了一项评估疼痛及应对策略参与情况的现患率调查。

结果

42%的参与者被归类为患有慢性疼痛。与丁丙诺啡患者相比,美沙酮患者的疼痛更严重,不过两组都报告了对日常活动的高度干扰,且有疼痛的参与者比无疼痛的参与者更频繁地前往急诊室。超过50%的参与者仅使用了两种应对策略(非处方药、祈祷)。

结论

结果表明,OMT患者中的疼痛很常见、严重且有显著损害。美沙酮患者报告的疼痛更严重,尤其是在过去24小时内疼痛更糟,不过疼痛对日常活动的干扰并没有因OMT药物而异。大多数有疼痛的参与者很少使用循证疼痛应对策略。增加OMT患者获得其他疼痛治疗策略的机会是立即进行干预的契机,而且不同OMT类型之间的相似性表明,干预措施无需针对美沙酮患者与丁丙诺啡患者进行定制。

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Pain Among High-Risk Patients on Methadone Maintenance Treatment.接受美沙酮维持治疗的高危患者的疼痛
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