表达CD4(+)CD25(high)CD45RO(+)CD62L(+)生物标志物的活化调节性T细胞可能是肝移植排斥反应的一个危险因素。
Activated Regulatory T Cells Expressing CD4(+)CD25(high)CD45RO(+)CD62L(+) Biomarkers Could Be a Risk Factor in Liver Allograft Rejection.
作者信息
Boix F, Millan O, San Segundo D, Mancebo E, Miras M, Rimola A, Fábrega E, Allende L, Minguela A, Paz-Artal E, López-Hoyos M, Brunet M, Muro M
机构信息
Immunology Service and Digestive Service, University Clinical Hospital Virgen Arrixaca-IMIB, Murcia, Spain.
Pharmacology Laboratory (CDB) and Liver Unit, Clinic Hospital, IDIBAPS, CIBERehd, Barcelona, Spain.
出版信息
Transplant Proc. 2015 Oct;47(8):2380-1. doi: 10.1016/j.transproceed.2015.09.007.
Activated regulatory T cells (aTregs) are nowadays a hot topic in organ transplantation to establish their role during acute rejection (AR) episodes. The aim of this multi-center study was to monitor the frequency of aTregs within the first year after transplantation in a cohort of first-time liver transplant recipients enrolled from 2010 to 2012. aTregs frequency was analyzed by means of flow cytometry. Patients who had AR showed higher levels of aTregs during first year after transplantation in comparison with patients who did not have higher levels. High levels of aTregs in liver recipients might be used as a biomarker of AR; however, further studies must be done to address the potential role of aTregs as biomarkers of AR in liver transplantation.
活化调节性T细胞（aTregs）如今是器官移植领域的一个热门话题，旨在明确其在急性排斥反应（AR）发作期间所起的作用。这项多中心研究的目的是监测2010年至2012年入组的首次肝移植受者队列在移植后第一年内aTregs的频率。通过流式细胞术分析aTregs频率。发生AR的患者在移植后第一年的aTregs水平高于未发生AR的患者。肝移植受者中高水平的aTregs可能用作AR的生物标志物；然而，必须开展进一步研究以探讨aTregs作为肝移植中AR生物标志物的潜在作用。
Zotero 插件