急性肾损伤后的进展：理解适应性不良修复过程以预测和确定治疗方法。
Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.
作者信息
Basile David P, Bonventre Joseph V, Mehta Ravindra, Nangaku Masaomi, Unwin Robert, Rosner Mitchell H, Kellum John A, Ronco Claudio
机构信息
Department of Cellular and Integrative Physiology and Department of Medicine, Division of Nephrology, Indiana University, Indianapolis, Indiana;
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;
出版信息
J Am Soc Nephrol. 2016 Mar;27(3):687-97. doi: 10.1681/ASN.2015030309. Epub 2015 Oct 30.
Recent clinical studies indicate a strong link between AKI and progression of CKD. The increasing prevalence of AKI must compel the nephrology community to consider the long-term ramifications of this syndrome. Considerable gaps in knowledge exist regarding the connection between AKI and CKD. The 13th Acute Dialysis Quality Initiative meeting entitled "Therapeutic Targets of Human Acute Kidney Injury: Harmonizing Human and Experimental Animal Acute Kidney Injury" convened in April of 2014 and assigned a working group to focus on issues related to progression after AKI. This article provides a summary of the key conclusions and recommendations of the group, including an emphasis on terminology related to injury and repair processes for both clinical and preclinical studies, elucidation of pathophysiologic alterations of AKI, identification of potential treatment strategies, identification of patients predisposed to progression, and potential management strategies.
近期的临床研究表明，急性肾损伤（AKI）与慢性肾脏病（CKD）的进展之间存在紧密联系。AKI患病率的不断上升必然促使肾脏病学界去考虑这一综合征的长期影响。关于AKI与CKD之间的联系，目前仍存在相当多的知识空白。2014年4月召开了第13届急性透析质量改进计划会议，会议主题为“人类急性肾损伤的治疗靶点：协调人类与实验动物急性肾损伤”，并指定了一个工作组专注于AKI后进展相关的问题。本文总结了该工作组的主要结论和建议，包括强调临床和临床前研究中与损伤及修复过程相关的术语，阐明AKI的病理生理改变，确定潜在的治疗策略，识别易进展的患者，以及潜在的管理策略。
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