Goss A N
Cleft Palate J. 1977 Apr;14(2):131-9.
Several hypotheses of post-fusion rupture of the previously intact palate as a cause of cleft palate have been advanced but with minimal supportive experimental evidence. In this investigation an animal model was evolved in which the intact palates of 19 1/2 day Sprague Dawley rat fetuses were surgically ruptured. Fetuses were grossly and histologically examined at 0.24, 48, and 72 hours after surgery. The operation resulted in a range of clefts including complete cleft of the hard and soft palate, isolated cleft of the hard palate and submucous cleft palate. There were no associated defects, and the fetal mortality was low. The various hypotheses of post-fusion rupture were reviewed, and it was concluded that this model supports the hypothesis that isolated clefts of the hard palate may result from post-fusion rupture and submucous cleft from late disturbances in palatal mesenchyme.
关于先前完整的腭部在融合后破裂作为腭裂成因的几种假说已被提出，但支持性的实验证据极少。在本研究中，建立了一种动物模型，对19.5天大的斯普拉格-道利大鼠胎儿的完整腭部进行手术破裂。在手术后0.24、48和72小时对胎儿进行大体和组织学检查。手术导致了一系列腭裂，包括硬腭和软腭完全裂开、孤立性硬腭裂和黏膜下腭裂。没有相关的缺陷，胎儿死亡率很低。对融合后破裂的各种假说进行了综述，得出的结论是，该模型支持以下假说：孤立性硬腭裂可能由融合后破裂导致，而黏膜下腭裂则由腭间充质的晚期紊乱引起。
