Wendl C M, Janke M, Jung W, Stroszczysnski C, Jung E M
Clin Hemorheol Microcirc. 2015 Oct 27;63(2):113-21. doi: 10.3233/CH-151966.
The aim of our study was to evaluate, whether the analysis of time intensity curves (TIC) of contrast enhanced ultrasound (CEUS) could help to differentiate between thyroid adenomas and carcinomas in daily clinical routine.B-mode, Colour Coded Doppler Sonography (CCDS), Power Doppler (PD) and CEUS were applied for 50 patients (27 men, 23 women; mean age 51 years, range 16-81 years).CEUS cine-sequences were analysed using time intensity curves (TIC) and calculating time to peak (TTP) as well as the area under the curve (AUC).All 20 patients with carcinomas presented with a complete wash-out in the late phase of CEUS while this occurred only in three out of the 30 patients with adenomas.Marked differences were observed between adenomas and carcinomas concerning the mean AUC in the surrounding thyroid tissue (p = 0.041). In addition, TTP differed clearly between the centre and the surrounding of the carcinomas (p < 0.05) as well as between TTP in the border area and the surrounding tissue (p = 0.01). CEUS in combination with TIC analysis allows a dynamic evaluation of the microvascularisation of thyroid nodules and is helpful for the differentiation of benign and malignant nodules.
我们研究的目的是评估在日常临床实践中，超声造影（CEUS）的时间强度曲线（TIC）分析是否有助于鉴别甲状腺腺瘤和癌。对50例患者（27例男性，23例女性；平均年龄51岁，范围16 - 81岁）进行了B超、彩色编码多普勒超声（CCDS）、能量多普勒（PD）和CEUS检查。使用时间强度曲线（TIC）分析CEUS电影序列，并计算峰值时间（TTP）以及曲线下面积（AUC）。所有20例癌患者在CEUS晚期均表现为完全消退，而30例腺瘤患者中只有3例出现这种情况。腺瘤和癌在甲状腺周围组织的平均AUC方面存在显著差异（p = 0.041）。此外，癌的中心与周边之间的TTP有明显差异（p < 0.05），边界区域与周边组织的TTP之间也有差异（p = 0.01）。CEUS结合TIC分析可对甲状腺结节的微血管化进行动态评估，有助于鉴别良性和恶性结节。
