Wang Ya-li, Yang Shu-zhen, Sun Wei-li, Shi Yu-zhong, Duan Hui-feng
The Third Psychiatric Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China.
The Seventh Psychiatric Department, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan Province, PR China.
Behav Brain Res. 2016 Feb 1;298(Pt B):301-9. doi: 10.1016/j.bbr.2015.10.040. Epub 2015 Oct 28.
Emotional and cognitive dysregulation in major depressive disorder (MDD) have been consistently considered to be attributed to structural and functional abnormalities in affective network (AN) and cognitive control network (CCN). This study was to investigate the functional connectivity (FC) patterns and altered functional interactions between both networks in MDD. We investigated resting-state functional connectivity magnetic resonance imaging in the AN and the CCN in 25 MDD and 35 healthy controls (HC). The seeds were from voxel-based morphometry (VBM) analysis results. Then FC within the AN was assessed from a seed placed in the left amygdala (AMG) and FC within CCN was determined by placing seeds in the right dorsolateral prefrontal cortex (DLPFC). Compared with HC, MDD showed reduced FC between left AMG and bilateral precuneus and right anterior cingulated cortex (ACC) within AN and reduced FC between right DLPFC and left cuneus, left lingual gyrus, and right ACC within CCN. An interaction hub of altered FC in MDD between AN and CCN located in the right ACC. Interestingly, the altered FC between right ACC and left AMG was negatively correlated with depressive symptom score while the altered FC between right ACC and DLPFC was positively correlated the executive function in MDD. The right ACC not only supports the cognitive and emotional processes, but also is an altered functional interaction hub between AN and CCN in MDD. It further suggest multiple sources of dysregulation in AN and CCN implicate both top-down cognitive control and bottom-up emotional expression dysfunction in MDD.
重度抑郁症（MDD）中的情绪和认知失调一直被认为归因于情感网络（AN）和认知控制网络（CCN）的结构和功能异常。本研究旨在调查MDD中这两个网络之间的功能连接（FC）模式及改变的功能相互作用。我们对25例MDD患者和35名健康对照者（HC）进行了静息态功能连接磁共振成像，分别观察AN和CCN。种子点来自基于体素的形态学测量（VBM）分析结果。然后，通过置于左侧杏仁核（AMG）的种子点评估AN内的FC，通过置于右侧背外侧前额叶皮质（DLPFC）的种子点确定CCN内的FC。与HC相比，MDD患者AN内左侧AMG与双侧楔前叶及右侧前扣带回皮质（ACC）之间的FC降低，CCN内右侧DLPFC与左侧楔叶、左侧舌回及右侧ACC之间的FC降低。MDD中AN和CCN之间FC改变的一个交互枢纽位于右侧ACC。有趣的是，右侧ACC与左侧AMG之间改变的FC与抑郁症状评分呈负相关，而右侧ACC与DLPFC之间改变的FC与MDD患者的执行功能呈正相关。右侧ACC不仅支持认知和情感过程，而且是MDD中AN和CCN之间改变的功能交互枢纽。这进一步表明，AN和CCN中失调的多种来源暗示了MDD中自上而下的认知控制和自下而上的情绪表达功能障碍。
