Somayajula Shanmuki, Vooturi Sudhindra, Jayalakshmi Sita
Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, India.
Department of Neurology, Krishna Institute of Medical Sciences, Secunderabad, Telangana, India.
Epilepsy Behav. 2015 Dec;53:37-42. doi: 10.1016/j.yebeh.2015.09.024. Epub 2015 Oct 28.
The current study evaluated the association between clinical variables and psychiatric disorders (PDs) in patients with juvenile myoclonic epilepsy (JME).
Consecutive patients with JME who had at least two years of regular follow-up from May 2011 to April 2014 formed the study population. The association between clinical and sociodemographic data with psychiatric evaluation on structured clinical interview and quality of life in epilepsy - 31 (QOLIE-31) was evaluated using logistic regression analysis.
Out of 165 patients in the current study, 77 (46.6%) patients were diagnosed with PDs; while 50 were categorized to having anxiety disorders, 27 patients had depressive disorders. The mean age of the study population was 25.35 ± 7.6 years with 37.52% women. Patients with PDs had lower overall QOLIE score (55.84 ± 13.07 vs 68.70 ± 11.23, p<0.001) and lower social function score (80.95 ± 19.22 vs 91.09 ± 14.74, p<0.001). Being married was the strongest predictor of depressive disorders (β=8.59; 95% CI, 1.44-51.28; p=0.018); whereas, lower emotional well-being (β=0.942; 95% CI, 0.907-0.978; p=0.002) was the only variable associated with anxiety disorders. Patients with depressive disorders had longer duration of PDs (11.85 ± 8.68 years vs 7.75 ± 6.70 years, p=0.039), and a majority of them were married (66.7% vs 26.0%, p=0.001). Patients with depressive disorders scored low on emotional well-being (50.81 ± 14.62 vs 61.02 ± 13.05, p=0.002), energy levels (52.78 ± 11.71 vs 62.80 ± 10.84, p<0.001), and social function (70.96 ± 20.69 vs 86.34 ± 16.16, p=0.001). Depressive disorders were more prevalent among married patients above 35 years of age (5.2% vs 36.8%, p=0.042).
Nearly half of the patients with JME had coexisting PDs. The psychological profile of anxiety disorders was different from depressive disorders in patients with JME. Depressive disorders were more prevalent among older patients with JME, and marriage was strongly associated with depressive disorders.
本研究评估青少年肌阵挛性癫痫（JME）患者的临床变量与精神障碍（PDs）之间的关联。
选取2011年5月至2014年4月期间至少有两年定期随访的连续性JME患者组成研究人群。采用逻辑回归分析评估临床和社会人口学数据与结构化临床访谈中的精神评估以及癫痫生活质量-31（QOLIE-31）之间的关联。
在本研究的165例患者中，77例（46.6%）被诊断为患有精神障碍；其中50例被归类为患有焦虑症，27例患有抑郁症。研究人群的平均年龄为25.35±7.6岁，女性占37.52%。患有精神障碍的患者总体QOLIE评分较低（55.84±13.07 vs 68.70±11.23，p<0.001），社会功能评分也较低（80.95±19.22 vs 91.09±14.74，p<0.001）。已婚是抑郁症的最强预测因素（β=8.59；95%CI，1.44 - 51.28；p=0.018）；而较低的情绪幸福感（β=0.942；95%CI，0.907 - 0.978；p=0.002）是与焦虑症相关的唯一变量。患有抑郁症的患者精神障碍持续时间更长（11.85±8.68年 vs 7.75±6.70年，p=0.039），且大多数已婚（66.7% vs 26.0%，p=0.001）。患有抑郁症的患者在情绪幸福感（50.81±14.62 vs 61.02±13.05，p=0.002）、精力水平（�2.78±11.71 vs 62.80±10.84，p<0.001）和社会功能（70.96±20.69 vs 86.34±16.16，p=0.001）方面得分较低。抑郁症在35岁以上的已婚患者中更为普遍（5.2% vs 36.8%，p=0.042）。
近一半的JME患者同时患有精神障碍。JME患者中焦虑症的心理特征与抑郁症不同。抑郁症在年龄较大的JME患者中更为普遍，且婚姻与抑郁症密切相关。
