Martelli Francesco Saverio, Bacci Giovanni, Martelli Maria Laura, Nobili Piero, Boddi Anna, Rosati Claudio, Fanti Elena
Microdentistry Florence, Italy.
Department of Biology, University of Florence, Italy.
Ig Sanita Pubbl. 2015 Jul-Aug;71(4):369-85.
The aim of this retrospective multicenter study was to verify the efficacy of Nd:YAG laser in the treatment of periodontal pockets infected by Epstein-Barr Virus (EBV) and Herpes Simplex Virus 1 (HSV1).
Subgingival plaque samples of 291 Italian periodontal patients were analyzed by Real Time PCR to evaluate the frequency of both viruses before and after Nd:YAG laser-assisted periodontal treatment.
Before treatment, EBV and HSV1 were observed in 29.9% and in 3.8% of periodontal patients respectively, while co-infection with both viruses was detected in 1.7% of cases. Periodontal Nd:YAG laser treatment ("Periodontal Biological Laser-Assisted Therapy", PERIOBLAST) produced statistical significant benefits, especially in EBV periodontal infection: 78.2% of EBV positive patients became EBV-negative following treatment.
Results of this preliminary study highlight that EBV is found in periodontal pockets more frequently than HSV1, supporting the theory of the potential role of EBV in the onset and progression of periodontal disease. Moreover, our data showed that Nd:YAG laser-assisted periodontal treatment (Perioblast) is also effective in case of viral infection, validating evidences that it represents a successful alternative approach to traditional periodontal protocols.
这项回顾性多中心研究的目的是验证钕钇铝石榴石激光（Nd:YAG激光）治疗由爱泼斯坦-巴尔病毒（EBV）和单纯疱疹病毒1型（HSV1）感染的牙周袋的疗效。
对291名意大利牙周病患者的龈下菌斑样本进行实时聚合酶链反应（Real Time PCR）分析，以评估Nd:YAG激光辅助牙周治疗前后两种病毒的感染频率。
治疗前，分别在29.9%的牙周病患者中观察到EBV，在3.8%的患者中观察到HSV1，而在1.7%的病例中检测到两种病毒的合并感染。牙周Nd:YAG激光治疗（“牙周生物激光辅助治疗”，PERIOBLAST）产生了统计学上的显著益处，尤其是在EBV牙周感染方面：78.2%的EBV阳性患者在治疗后变为EBV阴性。
这项初步研究的结果表明，EBV在牙周袋中的发现频率高于HSV1，支持了EBV在牙周病发生和发展中潜在作用的理论。此外，我们的数据表明，Nd:YAG激光辅助牙周治疗（Perioblast）在病毒感染的情况下也有效，证实了它是传统牙周治疗方案的一种成功替代方法的证据。
