Sarrazin D, Lê M G, Arriagada R, Contesso G, Fontaine F, Spielmann M, Rochard F, Le Chevalier T, Lacour J
Institut Gustave-Roussy, Villejuif, France.
Radiother Oncol. 1989 Mar;14(3):177-84. doi: 10.1016/0167-8140(89)90165-5.
A randomized trial was conducted at the Institut Gustave-Roussy (IGR) between 1972 and 1980 comparing tumorectomy and breast irradiation with modified radical mastectomy. One hundred and seventy-nine patients with an infiltrating breast carcinoma up to 20 mm in diameter at macroscopic examination were included: 88 had conservative management, and 91 a mastectomy. All patients had a low-axillary dissection with immediate histological examination. For the patients with positive axillary nodes, a complete axillary dissection was undertaken. Overall survival, distant metastasis, contralateral breast cancer and locoregional recurrence rates were not significantly different between the two treatment groups.
1972年至1980年间，古斯塔夫 - 鲁西研究所（IGR）进行了一项随机试验，比较肿瘤切除术加乳房放疗与改良根治性乳房切除术的效果。纳入了179例经宏观检查直径达20毫米的浸润性乳腺癌患者：88例接受了保守治疗，91例接受了乳房切除术。所有患者均进行了低位腋窝清扫并立即进行组织学检查。对于腋窝淋巴结阳性的患者，进行了完整的腋窝清扫。两个治疗组之间的总生存率、远处转移率、对侧乳腺癌发生率和局部区域复发率没有显著差异。
