Khan Muhammad Arif, Rahman Abdul, Almoukirish S, Jadoon Shehla, Momenah Tarek S
Department of Pediatric Cardiology, King Salman Heart Centre, King Fahad Medical City, Riyadh, KSA.
J Coll Physicians Surg Pak. 2015 Oct;25 Suppl 2:S81-3. doi: 10.2015/JCPSP.S81S83.
A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil. After 90 hours of 5-fluorouracil infusion, he developed severe retrosternal chest pain. Electrocardiography showed signs of acute pericarditis and was managed with ibuprofen and 5-fluorouracil was discontinued. The 5-fluorouracil rarely causes cardiac complications such as angina pectoris and pericarditis in adult patients. We report acute myopericarditis in a child caused by 5-fluorouracil, which is a very rare complication of 5-fluorouracil in pediatric age group.
一名9岁被诊断为鼻咽癌的男孩开始接受包含5-氟尿嘧啶的化疗方案。在输注5-氟尿嘧啶90小时后，他出现了严重的胸骨后胸痛。心电图显示有急性心包炎迹象，给予布洛芬治疗，同时停用5-氟尿嘧啶。5-氟尿嘧啶在成年患者中很少引起心绞痛和心包炎等心脏并发症。我们报告了一例由5-氟尿嘧啶引起的儿童急性心肌心包炎，这在儿童年龄组中是5-氟尿嘧啶非常罕见的并发症。
