CD99调节CXCL12诱导的人浆细胞趋化作用。
CD99 regulates CXCL12-induced chemotaxis of human plasma cells.
作者信息
Gil Minchan, Pak Hyo-Kyung, Lee A-Neum, Park Seo-Jung, Lee Yoonkyung, Roh Jin, Lee Hyunji, Chung Yoo-Sam, Park Chan-Sik
机构信息
Cell Dysfunction Research Center, University of Ulsan College of Medicine, Seoul, South Korea.
Cell Dysfunction Research Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
出版信息
Immunol Lett. 2015 Dec;168(2):329-36. doi: 10.1016/j.imlet.2015.10.015. Epub 2015 Nov 6.
Migration of plasma cells (PCs) is crucial for the control of PC survival and antibody production and is controlled by chemokines, most importantly by CXCL12. This study investigated the role of CD99 in CXCL12-induced PC migration. Among B cell subsets in the tonsils, CD99 expression was highest in PCs. CD99 expression increased during in vitro differentiation of germinal center B cells and was highest in PCs. CD99 engagement reduced chemotactic migration of PCs toward CXCL12 and reduced extracellular signal-regulated kinase (ERK) activation by CXCL12. An ERK inhibitor reduced CXCL12-mediated chemotactic migration, which suggests that ERK has a critical role in migration. CD99 engagement did not influence apoptosis, differentiation, or antibody secretion of PCs. We propose a novel role of CD99 in PCs that suppresses ERK activation and chemotactic migration of these cells.
浆细胞（PCs）的迁移对于控制PCs的存活和抗体产生至关重要，并且受趋化因子调控，其中最重要的是CXCL12。本研究调查了CD99在CXCL12诱导的PCs迁移中的作用。在扁桃体的B细胞亚群中，PCs中CD99的表达最高。在生发中心B细胞的体外分化过程中，CD99表达增加，且在PCs中最高。CD99的结合减少了PCs向CXCL12的趋化迁移，并降低了CXCL12对细胞外信号调节激酶（ERK）的激活。ERK抑制剂减少了CXCL12介导的趋化迁移，这表明ERK在迁移中起关键作用。CD99的结合不影响PCs的凋亡、分化或抗体分泌。我们提出CD99在PCs中具有一种新作用，即抑制这些细胞的ERK激活和趋化迁移。
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