2-氧代驱动的 N2 消除诱导苯并三唑的去羰基环化反应生成 6-氨基菲啶。
2-Oxo-Driven N2 Elimination Induced Decarbonylative Cyclization Reaction in Benzotriazoles to 6-Aminophenanthridines.
机构信息
Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM) , Jammu 180001, India.
Academy of Scientific and Innovative Research (AcSIR) , Jammu, India.
出版信息
Org Lett. 2015 Nov 20;17(22):5562-5. doi: 10.1021/acs.orglett.5b02699. Epub 2015 Nov 2.
An efficient functional group induced strategy for the synthesis of 6-aminophenanthridines (6AP) has been developed as a result of an in situ generated novel system "CO-CH(N1N2)". This reaction presents a new mode of N2 extrusion in benzotriazoles that later result in decarbonylative cyclization to 6AP. This method offers an easier protocol for the synthesis of 6AP from readily available inexpensive substrates.
一种高效的基于功能基团诱导的策略被开发用于 6-氨基菲啶（6AP）的合成，该策略源于一种原位生成的新型体系“CO-CH（N1N2）”。该反应呈现了一种苯并三唑中 N2 脱除的新模式，随后发生脱羰基环化生成 6AP。该方法提供了一种从易得且廉价的底物合成 6AP 的更简单的方案。
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