乙烯霉素的全合成及绝对构型确定。
Total Synthesis and Determination of the Absolute Configuration of Vinylamycin.
机构信息
The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
School of Pharmaceutical Science and Technology, Tianjin University , Tianjin, 300072, People's Republic of China.
出版信息
Org Lett. 2015 Dec 4;17(23):5725-7. doi: 10.1021/acs.orglett.5b02809. Epub 2015 Nov 2.
The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
根据与微硫霉素 A 和拉克西丁 A 的结构比较，预测了 vinylamycin 中三个未知手性中心的绝对构型，然后应用 vinylamycin 的全合成来确定三个未知手性中心为 14R、15R 和 16S。
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