The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300071, People's Republic of China.
School of Pharmaceutical Science and Technology, Tianjin University , Tianjin, 300072, People's Republic of China.
Org Lett. 2015 Dec 4;17(23):5725-7. doi: 10.1021/acs.orglett.5b02809. Epub 2015 Nov 2.
The absolute configurations of the three unknown chiral centers in vinylamycin were predicted according to the structural comparison with microtermolide A and rakicidin A, and then total syntheses of vinylamycin were applied to determine the three unknown chiral centers as 14R, 15R, and 16S.
根据与微硫霉素 A 和拉克西丁 A 的结构比较，预测了 vinylamycin 中三个未知手性中心的绝对构型，然后应用 vinylamycin 的全合成来确定三个未知手性中心为 14R、15R 和 16S。
