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[未出生胎儿的泌尿道梗阻性疾病]

[Obstructive disorders of the urinary tract in the unborn child].

作者信息

Brus F, Aarnoudse J G, Okken A

机构信息

Kliniek voor Kindergeneeskunde, Academisch Ziekenhuis Groningen.

出版信息

Tijdschr Kindergeneeskd. 1989 Feb;57(1):24-9.

PMID:2652373
Abstract

The history of a patient with signs of urinary tract obstruction in utero is presented. After this presentation pathophysiologic, diagnostic and therapeutic aspects of prenatal detected obstructive malformations of the urinary tract are discussed. Obstructions of the fetal urinary tract may cause damage to the developing renal parenchyma, impairment of the normal lung development and fetal growth retardation. The seriousness of obstruction and the time of appearance during pregnancy determine the severity of the damage to the unborn child. Optimum management in case of prenatal detected obstructive uropathies needs good information about renal function of the fetus, the presence of other structural defects or chromosomal abnormalities and also the maturity and state of development of the lungs. Besides careful ultrasonography of the fetus invasive methods of investigation may be necessary. In case of fetal obstructive uropathy intrauterine decompression or extrauterine decompression after an induced premature delivery can be considered. However a good renal function and the absence of other severe structural or chromosomal malformations are necessary. When the gestational age has come to 32 to 34 weeks and the lungs are mature enough decompression of the urinary tract after an induced premature delivery can be done. When pregnancy is less than 32 weeks of gestational age and the lungs are immature intrauterine decompression is possible. The most used technique of intrauterine decompression so far is insertion of a percutaneous amniotic-bladder catheter. Antenatal detected obstructive abnormalities of the fetal urinary tract need optimum perinatal care besides good information and support of the parents.

摘要

本文介绍了一名子宫内有尿路梗阻迹象患者的病史。在此之后,讨论了产前检测到的尿路梗阻性畸形的病理生理、诊断和治疗方面。胎儿尿路梗阻可能会对发育中的肾实质造成损害,影响正常肺发育并导致胎儿生长受限。梗阻的严重程度以及孕期出现的时间决定了对未出生胎儿损害的严重程度。对于产前检测到的梗阻性尿路疾病,最佳管理需要了解胎儿肾功能、是否存在其他结构缺陷或染色体异常,以及肺的成熟度和发育状况。除了仔细的胎儿超声检查外,可能还需要采用侵入性检查方法。对于胎儿梗阻性尿路疾病,可考虑在引产早产之后进行宫内减压或宫外减压。然而,胎儿需要有良好的肾功能且不存在其他严重的结构或染色体畸形。当孕周达到32至34周且肺部足够成熟时,可在引产早产之后进行尿路减压。当孕周小于32周且肺部未成熟时,可行宫内减压。迄今为止,最常用的宫内减压技术是经皮插入羊膜 - 膀胱导管。除了为父母提供充分的信息和支持外,产前检测到的胎儿尿路梗阻性异常还需要最佳的围产期护理。

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