Al-Gousous Jozef, Langguth Peter
Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.
Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany.
J Pharm Sci. 2016 Feb;105(2):509-511. doi: 10.1002/jps.24700. Epub 2016 Jan 11.
To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.
为研究钙离子对肠溶制剂崩解的影响，在试验介质存在和不存在钙的情况下，对肠溶阿司匹林片进行了崩解试验。结果表明，钙离子的存在会延缓肠溶制剂的崩解。这一尚未在科学文献中报道的发现，揭示了对来自饮食来源、钙补充剂、抗酸剂和/或磷酸盐结合剂中的钙影响肠溶制剂中药物吸收的可能性进行精心设计的详细研究的重要性。此外，它还表明有必要研究是否存在额外的营养辅料相互作用。
