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胆汁淤积性肝病患者自身免疫的管理。

The management of autoimmunity in patients with cholestatic liver diseases.

作者信息

Ali Ahmad H, Carey Elizabeth J, Lindor Keith D

机构信息

a 1 Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, USA.

b 2 Arizona State University, College of Health Solutions, Phoenix, AZ, USA.

出版信息

Expert Rev Gastroenterol Hepatol. 2016;10(1):73-91. doi: 10.1586/17474124.2016.1095088. Epub 2015 Nov 2.

Abstract

Cholestatic liver diseases are rare diseases that often lead to cirrhosis and its consequent complications. In addition to liver-related morbidity, patients with cholestatic liver diseases often suffer from autoimmune diseases that affect several organs and tissues. The robust and efficient data collection and collaboration between hepatologists and rheumatologists have led to significant advancements in understanding the relationship between the cholestatic liver diseases and associated autoimmune diseases. In this paper, we discuss the cholestatic liver diseases (primary biliary cirrhosis, primary sclerosing cholangitis and immunoglobulin G4 associated cholangitis) and associated autoimmune diseases.

摘要

胆汁淤积性肝病是一类罕见疾病,常导致肝硬化及其后续并发症。除了肝脏相关的发病率外,胆汁淤积性肝病患者还常患有影响多个器官和组织的自身免疫性疾病。肝病学家和风湿病学家之间强大而有效的数据收集与合作,在理解胆汁淤积性肝病与相关自身免疫性疾病之间的关系方面取得了重大进展。在本文中,我们将讨论胆汁淤积性肝病(原发性胆汁性肝硬化、原发性硬化性胆管炎和免疫球蛋白G4相关性胆管炎)及相关自身免疫性疾病。

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