Li Jing, Wen Hongling, Wang Zhiyu
Bing Du Xue Bao. 2015 Jul;31(4):468-73.
Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease (HFMD) and various neurological complications, including aseptic meningitis and neurogenic pulmonary edema in young children. HFMD caused by EV-A71 have broken out several times in the Asia-Pacific region since 2007. And it has been a serious threat to public health. There is no effective vaccine or antiviral drug. The pathogenesis of EV-A71 infection is unknown, and EV-A71 3C protein plays an irreplaceable role in replication and anti - innate immunity. Further research on EV-A71 3C protein is conducive to understand the pathogenesis of EV-A71 infection and antiviral drug.
肠道病毒A71型（EV-A71）可引起手足口病（HFMD）及多种神经并发症，包括幼儿的无菌性脑膜炎和神经源性肺水肿。自2007年以来，由EV-A71引起的手足口病已在亚太地区多次爆发，对公众健康构成严重威胁。目前尚无有效的疫苗或抗病毒药物。EV-A71感染的发病机制尚不清楚，且EV-A71 3C蛋白在病毒复制和抗先天免疫中发挥着不可替代的作用。对EV-A71 3C蛋白的进一步研究有助于了解EV-A71感染的发病机制及研发抗病毒药物。
