Zhou Kang, Zhou Yangzhao, Zhao Yuan, Tan Changming, Yuan Zhaoshun, Li Jianming, Liao Xiaobo, Gu Lu, Zhou Xinmin
The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
The Department of Cardiovascular Surgery of the 2nd XiangYa Hosptial, Central South University, Changsha, 410011, China.
Heart Lung Circ. 2016 Apr;25(4):371-7. doi: 10.1016/j.hlc.2015.08.021. Epub 2015 Oct 1.
This study was conducted to assess expression of Galectin-3 (Gal-3) in patients with different types of left ventricle (LV) hypertrophy geometry, and the relationship between Gal-3 expression and LV remodelling in patients with aortic valve stenosis (AS).
Galectin-3 expression was measured in the plasma and myocardia of AS patients who underwent an aortic valve replacement procedure.
The study enrolled 77 consecutive patients with severe AS. Fifty-five (71.43%) of the enrolled patients had concentric hypertrophy (CH group), and had the highest degree of fibrosis (27.10±5.25%; p<0.001) and expression of Gal-3 in both plasma (19.11±2.06 ng/mL) and myocardial tissue (3.01±0.79). There was a strong positive correlation between the levels of fibrosis and Gal-3 expression in both plasma (r=0.584, p<0.001) and myocardium (r=0.522, p<0.001). Relative wall thickness (RWT) was strongly correlated with Gal-3 expression in both myocardium (r=0.594, p<0.001) and plasma (r=0.323, p=0.005). Additionally, N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were positively correlated with both fibrosis (r=0.313, p=0.036) and LV mass index (r=0.559, p<0.001).
Concentric hypertrophy geometry was the most common type of myocardium remodelling, and AS patients with CH geometry showed the highest levels of Gal-3 expression. Galectin-3 levels were positively correlated with fibrosis and RWT, both of which are crucial indicators of geometric remodelling. Galectin-3 and NT-proBNP levels may be valuable prognostic predictors in AS patients with myocardial remodelling.
本研究旨在评估不同类型左心室（LV）肥厚几何形态患者中半乳糖凝集素-3（Gal-3）的表达情况，以及主动脉瓣狭窄（AS）患者中Gal-3表达与左心室重构之间的关系。
对接受主动脉瓣置换手术的AS患者的血浆和心肌中的Gal-3表达进行检测。
该研究纳入了77例连续的重度AS患者。其中55例（71.43%）患者为向心性肥厚（CH组），其纤维化程度最高（27.10±5.25%；p<0.001），血浆（19.11±2.06 ng/mL）和心肌组织（3.01±0.79）中的Gal-3表达也最高。血浆（r=0.584，p<0.001）和心肌（r=0.522，p<0.001）中的纤维化水平与Gal-3表达均呈强正相关。相对室壁厚度（RWT）与心肌（r=0.594，p<0.001）和血浆（r=0.323，p=0.005）中的Gal-3表达均密切相关。此外，N末端B型利钠肽原（NT-proBNP）水平与纤维化（r=0.313，p=0.036）和左心室质量指数（r=0.559，p<0.001）均呈正相关。
向心性肥厚几何形态是心肌重构最常见的类型，CH几何形态的AS患者Gal-3表达水平最高。Gal-3水平与纤维化和RWT呈正相关，而纤维化和RWT均是几何重构的关键指标。Gal-3和NT-proBNP水平可能是心肌重构AS患者有价值的预后预测指标。
