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Bumetanide for neonatal seizures-back from the cotside.

作者信息

Pressler Ronit M, Boylan Geraldine B, Marlow Neil, de Vries Linda S, Blennow Mats, Chiron Catherine, Cross J Helen, Hallberg Boubou, Hellström-Westas Lena, Jullien Vincent, Mangum Barry, Murphy Brendan, Murray Deirdre, Pons Gerard, Rennie Janet, Toet Mona C, Zohar Sarah

机构信息

Section of Clinical Neurosciences &Neonatal Unit, University College London, 30 Guilford Street, London WC1N 1EH, UK.

Neonatal Brain Research Group, INFANT Research Centre, University College Cork, Ireland.

出版信息

Nat Rev Neurol. 2015 Dec;11(12):724. doi: 10.1038/nrneurol.2015.116. Epub 2015 Nov 3.

DOI:10.1038/nrneurol.2015.116
PMID:26526530
Abstract
摘要

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Bumetanide for neonatal seizures-back from the cotside.布美他尼用于新生儿惊厥——来自床边的经验
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Question 1: Phenobarbital for preventing mortality and morbidity in full-term newborns with perinatal asphyxia in a resource-poor setting.问题1：在资源匮乏地区，苯巴比妥对预防足月围产期窒息新生儿的死亡率和发病率的作用。
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本文引用的文献

1
Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters.年龄和性别依赖性对苯巴比妥耐药性新生儿惊厥的易感性：氯离子共转运体的作用。
Front Cell Neurosci. 2015 May 12;9:173. doi: 10.3389/fncel.2015.00173. eCollection 2015.
2
Epilepsy: Neonatal seizures still lack safe and effective treatment.癫痫：新生儿惊厥仍缺乏安全有效的治疗方法。
Nat Rev Neurol. 2015 Jun;11(6):311-2. doi: 10.1038/nrneurol.2015.74. Epub 2015 Apr 28.
3
Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.
使用抗 NKCC1 基因治疗恢复神经元氯离子稳态可挽救唐氏综合征小鼠模型的认知缺陷。
Mol Ther. 2021 Oct 6;29(10):3072-3092. doi: 10.1016/j.ymthe.2021.05.023. Epub 2021 May 29.
4
Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.癫痫基准领域III：改善控制癫痫发作及癫痫相关病症且无副作用的治疗方案。
Epilepsy Curr. 2020 Jan-Feb;20(1_suppl):23S-30S. doi: 10.1177/1535759719895279. Epub 2020 Jan 22.
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The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia.抗炎化合物坎地沙坦西立酯可改善新生鼠缺氧模型的神经结局。
Front Immunol. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752. eCollection 2019.
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Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model.药物抵抗性新生儿癫痫发作：化学诱导惊厥模型的关键机制见解。
Dev Neurobiol. 2018 Nov;78(11):1117-1130. doi: 10.1002/dneu.22634. Epub 2018 Aug 31.
7
Acute symptomatic seizures in term neonates: Etiologies and treatments.足月新生儿急性症状性发作：病因和治疗。
Semin Fetal Neonatal Med. 2018 Jun;23(3):183-190. doi: 10.1016/j.siny.2018.02.002. Epub 2018 Feb 6.
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Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.氯离子调节异常、癫痫发作与脑水肿：一种具有治疗潜力的关系。
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J Pediatr. 2013 Aug;163(2):465-70. doi: 10.1016/j.jpeds.2013.01.041. Epub 2013 Feb 26.
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Cooling for newborns with hypoxic ischaemic encephalopathy.对患有缺氧缺血性脑病的新生儿进行降温治疗。
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Cell Biochem Biophys. 2013 Apr;65(3):381-98. doi: 10.1007/s12013-012-9442-2.
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Cooling and seizure burden in term neonates: an observational study.足月新生儿的降温与癫痫发作负担：一项观察性研究。
Arch Dis Child Fetal Neonatal Ed. 2012 Jul;97(4):F267-72. doi: 10.1136/archdischild-2011-300716. Epub 2012 Jan 3.
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Optimal designs for estimating the most successful dose.用于估计最有效剂量的最优设计。
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Potential benefit of Bayesian forecasting for therapeutic drug monitoring in neonates.
Ther Drug Monit. 2002 Feb;24(1):9-14. doi: 10.1097/00007691-200202000-00002.