偏头痛与卵圆孔未闭关联的病例对照研究的荟萃分析。

A meta-analysis of case-control studies of the association of migraine and patent foramen ovale.

作者信息

Takagi Hisato, Umemoto Takuya

机构信息

Department of Cardiovascular Surgery, Shizuoka Medical Center, Shizuoka, Japan.

出版信息

J Cardiol. 2016 Jun;67(6):493-503. doi: 10.1016/j.jjcc.2015.09.016. Epub 2015 Oct 31.

DOI:10.1016/j.jjcc.2015.09.016

PMID:26527111

Abstract

OBJECTIVES

To establish quantitative evidence, we performed the first meta-analysis of case-control studies assessing the relationship between migraine and patent foramen ovale (PFO).

METHODS

MEDLINE and EMBASE were searched through April 2015 using PubMed and OVID. Eligible studies were case-control studies reporting PFO (or migraine) prevalence in migraine patients versus no-migraine subjects (or PFO patients versus no-PFO subjects).

RESULTS

Of 395 potentially relevant articles screened initially, 21 eligible studies enrolling a total of 5572 participants were identified and included. Pooled analyses demonstrated statistically significant 3.36-fold migraine-with-aura [odds ratio (OR), 3.36; 95% confidence interval (CI), 2.04-5.55; p<0.00001] and 2.46-fold migraine-with/without-aura prevalence (OR, 2.46; 95% CI, 1.55-3.91; p=0.0001) but statistically non-significant 1.30-fold migraine-without-aura prevalence (OR, 1.30; 95% CI, 0.85-1.99; p=0.22) in PFO patients relative to no-PFO subjects.

CONCLUSIONS

PFO is associated with 3.4-fold migraine-with-aura and 2.5-fold migraine-with/without-aura prevalence but unassociated with migraine-without-aura prevalence.

摘要

目的

为了建立定量证据，我们对评估偏头痛与卵圆孔未闭（PFO）之间关系的病例对照研究进行了首次荟萃分析。

方法

通过使用PubMed和OVID检索截至2015年4月的MEDLINE和EMBASE。符合条件的研究为报告偏头痛患者与非偏头痛受试者中PFO（或偏头痛）患病率的病例对照研究（或PFO患者与非PFO受试者）。

结果

在最初筛选的395篇潜在相关文章中，确定并纳入了21项符合条件的研究，共纳入5572名参与者。汇总分析显示，与非PFO受试者相比，PFO患者中伴有先兆偏头痛的患病率有统计学显著的3.36倍升高[比值比（OR），3.36；95%置信区间（CI），2.04 - 5.55；p<0.00001]，伴有/不伴有先兆偏头痛的患病率有2.46倍升高（OR，2.46；95% CI，1.55 - 3.91；p = 0.0001），但不伴有先兆偏头痛的患病率有1.30倍升高无统计学意义（OR，1.30；95% CI，0.85 - 1.99；p = 0.22）。