Yu Zhipeng, Zhao Wenzhu, Ding Long, Yu Yiding, Liu Jingbo
College of Food Science and Engineering, Bohai University, Jinzhou 121013, P.R. China.
Lab of Nutrition and Functional Food, Jilin University, Changchun 130062, P.R. China.
Food Funct. 2016 Jan;7(1):491-7. doi: 10.1039/c5fo00697j.
Three novel egg white-derived peptides were demonstrated to display in vitro activities against the angiotensin converting enzyme (ACE). A further study was conducted to assess their anxiolytic-like effects upon spontaneously hypertensive rats (SHRs) after an oral administration of the peptides, which showed the same behavioral performance as that using an elevated plus maze (EPM). In the EPM experiment, the behavioral effects of peptides TNGIIR, RVPSL, and QIGLF were investigated at doses ranging from 5 to 50 mg kg(-1), with records of the number of entries by the rats into the open arms, the time the rats spent in the open arms, and the total amount of entries into the open + closed arms. The results showed that the peptides TNGIIR and RVPSL, in a range of 5-50 mg kg(-1), exerted an anxiolytic effect on the SHRs. These results suggested that the egg white derived peptides TNGIIR and RVPSL could be considered as possible functional food or food ingredients due to their in vivo anti-stress and anti-anxiety effects on the SHRs.
三种新的蛋清衍生肽被证明在体外对血管紧张素转换酶（ACE）具有活性。进一步开展了一项研究，以评估这些肽口服给药后对自发性高血压大鼠（SHR）的抗焦虑样作用，结果显示其行为表现与使用高架十字迷宫（EPM）时相同。在EPM实验中，研究了肽TNGIIR、RVPSL和QIGLF在5至50 mg kg(-1)剂量范围内的行为效应，记录大鼠进入开放臂的次数、在开放臂停留的时间以及进入开放 + 封闭臂的总次数。结果表明，肽TNGIIR和RVPSL在5至50 mg kg(-1)范围内对SHR发挥了抗焦虑作用。这些结果表明，蛋清衍生肽TNGIIR和RVPSL因其对SHR的体内抗应激和抗焦虑作用，可被视为潜在的功能性食品或食品成分。
