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MetaNetX/MNXref——代谢物与生化反应的整合,以汇集基因组规模的代谢网络。

MetaNetX/MNXref--reconciliation of metabolites and biochemical reactions to bring together genome-scale metabolic networks.

作者信息

Moretti Sébastien, Martin Olivier, Van Du Tran T, Bridge Alan, Morgat Anne, Pagni Marco

机构信息

Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland Department of Ecology and Evolution, Biophore, Evolutionary Bioinformatics group, University of Lausanne, Lausanne 1015, Switzerland.

Vital-IT group, SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.

出版信息

Nucleic Acids Res. 2016 Jan 4;44(D1):D523-6. doi: 10.1093/nar/gkv1117. Epub 2015 Nov 2.

Abstract

MetaNetX is a repository of genome-scale metabolic networks (GSMNs) and biochemical pathways from a number of major resources imported into a common namespace of chemical compounds, reactions, cellular compartments--namely MNXref--and proteins. The MetaNetX.org website (http://www.metanetx.org/) provides access to these integrated data as well as a variety of tools that allow users to import their own GSMNs, map them to the MNXref reconciliation, and manipulate, compare, analyze, simulate (using flux balance analysis) and export the resulting GSMNs. MNXref and MetaNetX are regularly updated and freely available.

摘要

MetaNetX是一个基因组规模代谢网络(GSMNs)和生化途径的储存库,这些数据来自多个主要资源,并被导入到一个由化合物、反应、细胞区室(即MNXref)和蛋白质组成的通用命名空间中。MetaNetX.org网站(http://www.metanetx.org/)提供对这些整合数据的访问,以及各种工具,允许用户导入自己的GSMNs,将它们映射到MNXref协调中,并对所得的GSMNs进行操作、比较、分析、模拟(使用通量平衡分析)和导出。MNXref和MetaNetX会定期更新且免费提供。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f534/4702813/86a22d02f629/gkv1117fig1.jpg

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