胶质瘤患者的癫痫：机制、管理及抗惊厥治疗的影响
Epilepsy in glioma patients: mechanisms, management, and impact of anticonvulsant therapy.
作者信息
Armstrong Terri S, Grant Robin, Gilbert Mark R, Lee Jong Woo, Norden Andrew D
机构信息
Department of Family Health, University of Texas Health Science Center at Houston, Houston, Texas (T.S.A.); Edinburgh Centre for Neuro-Oncology, Edinburgh, UK (R.G.); Neuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (M.R.G.); Division of EEG and Epilepsy, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts (J.W.L.); Center for Neuro-Oncology, Dana-Farber Cancer Institute; Division of Cancer Neurology, Department of Neurology, Brigham and Women's Hospital; and Harvard Medical School, Boston, Massachusetts (A.D.N.).
出版信息
Neuro Oncol. 2016 Jun;18(6):779-89. doi: 10.1093/neuonc/nov269. Epub 2015 Nov 2.
Seizures are a well-recognized symptom of primary brain tumors, and anticonvulsant use is common. This paper provides an overview of epilepsy and the use of anticonvulsants in glioma patients. Overall incidence and mechanisms of epileptogenesis are reviewed. Factors to consider with the use of antiepileptic drugs (AEDs) including incidence during the disease trajectory and prophylaxis along with considerations in the selection of anticonvulsant use (ie, potential side effects, drug interactions, adverse effects, and impact on survival) are also reviewed. Finally, areas for future research and exploring the pathophysiology and use of AEDs in this population are also discussed.
癫痫发作是原发性脑肿瘤一种广为人知的症状，抗惊厥药物的使用很常见。本文概述了癫痫以及抗惊厥药物在胶质瘤患者中的使用情况。对癫痫的总体发病率和癫痫发生机制进行了综述。还综述了使用抗癫痫药物（AEDs）时需要考虑的因素，包括疾病进程中的发病率和预防措施，以及选择抗惊厥药物使用时的注意事项（即潜在副作用、药物相互作用、不良反应和对生存的影响）。最后，还讨论了未来研究的领域以及探索AEDs在该人群中的病理生理学和应用。
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