泛素E3连接酶SCF和APC/C在人类癌症中的重要性。
The Importance of Ubiquitin E3 Ligases, SCF and APC/C, in Human Cancers.
作者信息
Bochis Ovidiu Vasile, Fetica Bogdan, Vlad Catalin, Achimas-Cadariu Patriciu, Irimie Alexandru
机构信息
Department of Medical Oncology, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Pathology, "Prof. Dr. Ion Chiricuta" Institute of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
出版信息
Clujul Med. 2015;88(1):9-14. doi: 10.15386/cjmed-377. Epub 2015 Jan 28.
A normal evolution of the cell-cycle phases consists of multiple consecutive events, which makes it a highly complex process. Its preservation is regulated by Cyclin-Cdks (cyclin-dependent kinases) interactions and protein degradation, which is often controlled by the ubiquitin-mediated proteolysis. The goal of this review is to emphasize the most important features of the regulation of the cell-cycle involved in cancerogenesis, by presenting the involvement of E3 ubiquitin ligases SCF (Skp1-Cul1-F-box protein) and APC/C (Anaphase-promoting complex/cyclosome) in human malignancies. Also, we discuss the importance of the ubiquitin proteasome pathway blockade in cancer treatment. We know that a better understanding of the regulatory biology of the cell cycle can lead to the development of new target therapies for cancer.
细胞周期各阶段的正常演变由多个连续事件组成，这使其成为一个高度复杂的过程。其维持由细胞周期蛋白 - 细胞周期蛋白依赖性激酶（Cyclin - Cdks）相互作用和蛋白质降解来调节，而这通常由泛素介导的蛋白水解控制。本综述的目的是通过阐述E3泛素连接酶SCF（Skp1 - Cul1 - F - box蛋白）和后期促进复合物/细胞周期体（APC/C）在人类恶性肿瘤中的作用，强调参与肿瘤发生的细胞周期调控的最重要特征。此外，我们还讨论了泛素蛋白酶体途径阻断在癌症治疗中的重要性。我们知道，更好地理解细胞周期的调控生物学可以推动癌症新靶向治疗方法的开发。
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