Sengar D P, Couture R A, Jindal S L, Lazarovits A I
Department of Laboratory Medicine, Ottawa General Hospital, London, Ontario, Canada.
Transplant Proc. 1989 Apr;21(2):3328-9.
Class II HLA matching, especially HLA-DQ and DR, significantly improved allograft survival. HLA-DQ and DR matching may also be associated, in general, with a quiescent posttransplantation course, reduced incidence of SRRE, and somewhat better response to OKT3 rescue therapy. We conclude that the matching of class II HLA remains an important predictor of transplant outcome in CyA-treated patients and should form the primary basis of organ sharing.
II类HLA配型，尤其是HLA-DQ和DR配型，显著提高了移植器官的存活率。一般来说，HLA-DQ和DR配型还可能与移植后病情平稳、SRRE发生率降低以及对OKT3挽救治疗的反应稍好有关。我们得出结论，II类HLA配型仍然是环孢素A治疗患者移植结果的重要预测指标，应成为器官分配的主要依据。
