MacDonald A S, Belitsky P, Bitter-Suermann H, Cohen A, Crocker J, Ogborn M
Transplant Service, Dalhousie University, Halifax, Nova Scotia, Canada.
Transplant Proc. 1989 Apr;21(2):3364-5.
The results of 120 LRD kidney grafts, 49 HLA identical and 71 haploidentical, performed between 1981 and 1987 during the CyA era have been analyzed. The reduction in the incidence of rejection in diploidenticals with CyA vs AZA did not increase short- or long-term graft survival but was accompanied by worse kidney function and a greater need for antihypertensives. CyA did improve the results in haploidentical recipients over our historical experience, although prior sensitization was still a major hazard in this group.
对1981年至1987年环孢素（CyA）时代进行的120例活体亲属供肾移植结果进行了分析，其中49例为HLA全相同供体，71例为单倍体相同供体。与硫唑嘌呤（AZA）相比，CyA使全相同供体移植受者的排斥反应发生率降低，但并未提高短期或长期移植肾存活率，反而伴有肾功能较差以及对降压药的需求增加。与我们既往的经验相比，CyA确实改善了单倍体相同供体受者的移植结果，尽管预先致敏在该组中仍然是一个主要危险因素。
