Adler Alexandra R, Charnin Jonathan A, Quraishi Sadeq A
From the *Department of Medicine, Cambridge Health Alliance, Cambridge, Massachusetts; †Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts; and ‡Department of Anesthesia, Harvard Medical School, Boston, Massachusetts.
A A Case Rep. 2015 Nov 1;5(9):156-9. doi: 10.1213/XAA.0000000000000217.
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed to patients of all ages. Although generally considered safe, therapy with SSRIs can be complicated by serotonin syndrome (SS), a life-threatening condition. We present a case of SS that developed in a young man who was receiving a stable dose of fluoxetine and then received several commonly used medications during an emergent appendectomy. Because polypharmacy in the perioperative setting may trigger SS, it is important for anesthesiologists to be cognizant of the interactions between SSRIs and common perioperative medications to formulate anesthetic plans that optimize patient safety.
选择性5-羟色胺再摄取抑制剂（SSRI）被广泛用于各年龄段的患者。尽管通常被认为是安全的，但使用SSRI进行治疗可能会并发5-羟色胺综合征（SS），这是一种危及生命的病症。我们报告了一例SS病例，该病例发生在一名年轻男性身上，他一直在接受稳定剂量的氟西汀治疗，然后在急诊阑尾切除术中又接受了几种常用药物。由于围手术期的联合用药可能引发SS，麻醉医生了解SSRI与围手术期常用药物之间的相互作用，对于制定优化患者安全的麻醉方案很重要。
