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因胸痛入院但无心肌梗死的患者与出院患者再次就诊于急诊科的风险与高敏心肌肌钙蛋白T水平的关系。

Risk of revisits to the emergency department in admitted versus discharged patients with chest pain but without myocardial infarction in relation to high-sensitivity cardiac troponin T levels.

作者信息

Bandstein Nadia, Ljung Rickard, Holzmann Martin J

机构信息

Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Internal Medicine, Karolinska Institutet, Stockholm, Sweden.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

Int J Cardiol. 2016 Jan 15;203:341-6. doi: 10.1016/j.ijcard.2015.10.170. Epub 2015 Oct 21.

DOI:10.1016/j.ijcard.2015.10.170
PMID:26529084
Abstract

BACKGROUND

Recent studies have indicated that it may be safe to discharge chest pain patients with an initial high-sensitivity cardiac troponin T (hs-cTnT) level of <5 ng/L from the emergency department (ED) without further evaluation. We sought to assess the effects of discharge from the ED versus admission to hospital on downstream resource utilisation in low-risk chest pain patients.

METHODS

We included all patients who sought medical attention for chest pain during 2 years at the Karolinska University Hospital and who had no myocardial infarction (MI). Adjusted hazard ratios (HRs) were calculated for revisits to the ED, revisits leading to hospitalisation, coronary angiography, or revascularisation during follow-up for admitted compared with discharged patients.

RESULTS

13,046 patients were included, of whom 7694 (59%) had at least one revisit to the ED during a mean of 516 days' follow-up. Admitted patients with hs-cTnT levels of <5 ng/L were 12% more likely to return to the ED during follow-up (HR 1.12, 95% confidence interval (CI) 1.04 to 1.20), and 24% more likely to return to the ED within 30 days (HR 1.24, CI 1.05 to 1.46) than patients who were discharged. The risk of revisit leading to hospitalisation was almost doubled, and the likelihood of undergoing coronary angiography or revascularisation was three-fold in admitted compared with discharged patients.

CONCLUSIONS

Increased risks of revisit to the ED, hospitalisation, coronary angiography, and revascularisation were observed when patients with chest pain and hs-cTnT levels of <5 ng/L were admitted instead of discharged home.

摘要

背景

近期研究表明,对于初始高敏心肌肌钙蛋白T(hs-cTnT)水平<5 ng/L的胸痛患者,在急诊科(ED)不经进一步评估就予以出院可能是安全的。我们旨在评估低风险胸痛患者从急诊科出院与入院对下游资源利用的影响。

方法

我们纳入了卡罗林斯卡大学医院2年内因胸痛就诊且无心肌梗死(MI)的所有患者。计算了入院患者与出院患者在随访期间再次到急诊科就诊、再次就诊导致住院、进行冠状动脉造影或血运重建的调整风险比(HR)。

结果

共纳入13046例患者,其中7694例(59%)在平均516天的随访期间至少有一次到急诊科复诊。hs-cTnT水平<5 ng/L的入院患者在随访期间返回急诊科的可能性比出院患者高12%(HR 1.12,95%置信区间(CI)1.04至1.20),在30天内返回急诊科的可能性高24%(HR 1.24,CI 1.05至1.46)。与出院患者相比,入院患者再次就诊导致住院的风险几乎翻倍,进行冠状动脉造影或血运重建的可能性是其三倍。

结论

对于hs-cTnT水平<5 ng/L的胸痛患者,入院而非出院回家会增加再次到急诊科就诊、住院、冠状动脉造影和血运重建的风险。

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