Rodrigues Débora Olmedo, Bristot Ivi Juliana, Klamt Fábio, Frizzo Marcos Emílio
Laboratory of Cellular Neurobiology, Department of Morphological Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Laboratory of Cellular Biochemistry, Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Neurotoxicology. 2015 Dec;51:192-7. doi: 10.1016/j.neuro.2015.10.014. Epub 2015 Oct 31.
Mitochondrial damage and declines in ATP levels have been recently attributed to sertraline. The effects of sertraline on different parameters were investigated in washed platelets from 18 healthy male volunteers, after 24h of drug exposure. Sertraline toxicity was observed only at the highest concentrations, 30 and 100 μM, which significantly reduced platelet viability to 76 ± 3% and 20 ± 2%, respectively. The same concentrations significantly decreased total ATP to 73 ± 3% and 13 ± 2%, respectively. Basal values of glycogen were not significantly affected by sertraline treatment. Glutamate uptake was significantly reduced after treatment with 3, 30 and 100 μM, by 28 ± 6%, 32 ± 5% and 54 ± 4%, respectively. Our data showed that sertraline at therapeutic concentrations does not compromise platelet viability and ATP levels, but they suggest that in a situation where extracellular glutamate levels are potentially increased, sertraline might aggravate an excitotoxic condition.
线粒体损伤和三磷酸腺苷（ATP）水平下降最近被归因于舍曲林。在18名健康男性志愿者的洗涤血小板中，研究了舍曲林在药物暴露24小时后对不同参数的影响。仅在最高浓度30和100μM时观察到舍曲林毒性，这分别使血小板活力显著降低至76±3%和20±2%。相同浓度分别使总ATP显著降低至73±3%和13±2%。糖原的基础值不受舍曲林治疗的显著影响。用3、30和100μM治疗后，谷氨酸摄取分别显著降低28±6%、32±5%和54±4%。我们的数据表明，治疗浓度的舍曲林不会损害血小板活力和ATP水平，但表明在细胞外谷氨酸水平可能升高的情况下，舍曲林可能会加重兴奋性毒性状况。
