伴随诊断经济评估中检测准确性的重要性。
The importance of test accuracy in economic evaluations of companion diagnostics.
作者信息
San Miguel Lorena, Hulstaert Frank
机构信息
KCE Belgian Health Care Knowledge Centre, Doorbuilding (9th Floor), Boulevard du Jardin Botanique 55, 1000 Brussels, Belgium.
出版信息
J Comp Eff Res. 2015 Nov;4(6):569-77. doi: 10.2217/cer.15.41. Epub 2015 Nov 3.
BACKGROUND
Economic evaluations of companion diagnostics often fail to include the impact that tests have on the overall economic value of test-drug combinations.
METHODS
To illustrate the importance of test accuracy on the cost-effectiveness of companion diagnostics by means of examples. Data were extracted from the literature.
RESULTS
The accuracy of a test and in particularly its specificity, is often more influential on the overall cost-effectiveness results than the price of the test. Specificity becomes more crucial when prevalence of the biomarker is low. Multiple, simultaneous testing faces specific challenges regarding its overall specificity.
CONCLUSION
This article opens a discussion on some fundamental points linked to economic evaluations of test-therapy combinations.
背景
伴随诊断的经济评估往往未能纳入检测对检测-药物组合整体经济价值的影响。
方法
通过实例说明检测准确性对伴随诊断成本效益的重要性。数据从文献中提取。
结果
检测的准确性，尤其是其特异性，通常比检测价格对整体成本效益结果的影响更大。当生物标志物的患病率较低时，特异性变得更为关键。多重同时检测在其整体特异性方面面临特定挑战。
结论
本文开启了关于与检测-治疗组合经济评估相关的一些基本要点的讨论。
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