Gil Polo Cecilia, Cubo Delgado Esther, Mateos Cachorro Ana, Rivadeneyra Posadas Jéssica, Mariscal Pérez Natividad, Armesto Formoso Diana
Neurology Department, Hospital Universitario de Burgos, Burgos, Spain.
Ann Nutr Metab. 2015;67(4):267-73. doi: 10.1159/000441328. Epub 2015 Nov 4.
Little is known about the energy needs in Huntington's disease (HD). The aims of this study are to analyze and compare the total energy expenditure (TEE) and energy balance (EB) in a representative sample of HD patients with healthy controls.
This is an observational, case-control single-center study. Food caloric energy intake (EI) and TEE were considered for estimating EB. A dietary recall questionnaire was used to assess the EI. TEE was computed as the sum of resting energy expenditure (REE), measured by indirect calorimetry and physical activity (PA) monitored by an actigraph.
A total of 22 patients were included (36% men, mean age 50.3 ± 15.6 years, motor Unified Huntington's Disease Scale 27.9 ± 23.7, total functional capacity 11.0 (7.0-13.0), EI 38.6 ± 10.0 kcal/kg, PA 5.3 (3.0-7.4) kcal/kg, REE 30.9 ± 6.4 kcal/kg, TEE 2,023.4 (1,592.0-2,226.5) kcal/day) and 18 controls (50% men, mean age 47.4 ± 13.8 years, EI 38.6 ± 10.3 kcal/kg, PA 8.4 (5.0-13.8) kcal/kg, REE 30.8 ± 6.6 kcal/kg, TEE 2,281.0 (2,057.3-2,855.3) kcal/day). TEE was significantly lower in patients compared to controls (p = 0.03). PA was lower in patients compared to controls (p = 0.02).
Although patients with HD appeared to have lower energy expenditure, mainly due to decreased voluntary PA, they were still able to maintain their energy needs with an adequate food intake. © 2015 S. Karger AG, Basel.
人们对亨廷顿舞蹈症（HD）的能量需求了解甚少。本研究旨在分析并比较HD患者代表性样本与健康对照者的总能量消耗（TEE）和能量平衡（EB）。
这是一项单中心观察性病例对照研究。通过食物热量能量摄入（EI）和TEE来估算EB。采用饮食回顾问卷评估EI。TEE计算为通过间接测热法测得的静息能量消耗（REE）与通过活动记录仪监测的身体活动（PA）之和。
共纳入22例患者（男性占36%，平均年龄50.3±15.6岁，运动统一亨廷顿舞蹈症量表评分为27.9±23.7，总功能能力为11.0（7.0 - 13.0），EI为38.6±10.0千卡/千克，PA为5.3（3.0 - 7.4）千卡/千克，REE为30.9±6.4千卡/千克，TEE为2,023.4（1,592.0 - 2,226.5）千卡/天）和18例对照者（男性占50%，平均年龄47.4±13.8岁，EI为38.6±10.3千卡/千克，PA为8.4（5.0 - 13.8）千卡/千克，REE为30.8±6.6千卡/千克，TEE为2,281.0（2,057.3 - 2,855.3）千卡/天）。患者的TEE显著低于对照者（p = 0.03）。患者的PA低于对照者（p = 0.02）。
尽管HD患者的能量消耗似乎较低，主要是由于自主PA减少，但他们仍能够通过充足的食物摄入来维持能量需求。© 2015 S. Karger AG，巴塞尔。
