Monajjemi Majid
Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Biophys Chem. 2015 Dec;207:114-27. doi: 10.1016/j.bpc.2015.10.003. Epub 2015 Oct 23.
Cell membrane has a unique feature of storing biological energies in a physiologically relevant environment. This study illustrates a capacitor model of biological cell membrane including DPPC structures. The electron density profile models, electron localization function (ELF) and local information entropy have been applied to study the interaction of proteins with lipid bilayers in the cell membrane. The quantum and coulomb blockade effects of different thicknesses in the membrane have also been specifically investigated. It has been exhibited the quantum effects can appear in a small region of the free space within the membrane thickness due to the number and type of phospholipid layers. In addition, from the viewpoint of quantum effects by Heisenberg rule, it is shown the quantum tunneling is allowed in some micro positions while it is forbidden in other forms of membrane capacitor systems. Due to the dynamical behavior of the cell membrane, its capacitance is not fixed which results a variable capacitor. In presence of the external fields through protein trance membrane or ions, charges exert forces that can influence the state of the cell membrane. This causes to appear the charge capacitive susceptibility that can resonate with self-induction of helical coils; the resonance of which is the main reason for various biological pulses.
细胞膜具有在生理相关环境中储存生物能量的独特特性。本研究阐述了一种包含二棕榈酰磷脂酰胆碱（DPPC）结构的生物细胞膜电容模型。电子密度分布模型、电子定位函数（ELF）和局部信息熵已被用于研究蛋白质与细胞膜中脂质双层的相互作用。还特别研究了膜中不同厚度的量子和库仑阻塞效应。研究表明，由于磷脂层的数量和类型，量子效应可能出现在膜厚度内自由空间的一个小区域。此外，从海森堡规则的量子效应观点来看，在某些微观位置允许量子隧穿，而在其他形式的膜电容系统中则被禁止。由于细胞膜的动态行为，其电容不是固定的，这导致了一个可变电容器。在通过蛋白质跨膜或离子存在外部场的情况下，电荷施加的力会影响细胞膜的状态。这导致出现电荷电容敏感性，其可与螺旋线圈的自感发生共振；这种共振是各种生物脉冲的主要原因。
