A rational approach to the use of hormonal replacement therapy in postmenopausal and older women.

This report reviews the use of hormonal therapy in postmenopausal women and gives specific attention to its benefits in the older patients. Concomitant use of progestin is recommended for all but the very old who are being treated for urogenital problems. Strategies for minimizing withdrawal bleeding and the adverse impacts of progestins on lipoprotein subfractions are discussed.