Fukumoto Seiji
Nihon Rinsho. 2015 Oct;73(10):1696-700.
Parathyroid hormone(PTH) is essential for maintaining serum calcium level. PTH increases serum calcium partly by enhancing bone resorption. Therefore, persistent excessive actions of PTH result in cortical bone loss by increased bone resorption. In contrast, intermittent injections of PTH preparations increase trabecular bone mainly by enhancing bone formation. Teriparatide is a peptide with 34 amino acids corresponding to the N-terminal portion of PTH. Both once daily and once weekly subcutaneous injections of teriparatide are available in Japan. Teriparatide was shown to prevent vertebral fractures. In addition, once daily injections of teriparatide also reduce non-vertebral fractures. However, there still remain several unanswered questions about the precise mechanisms of actions of teriparatide preparations.
甲状旁腺激素（PTH）对于维持血清钙水平至关重要。PTH部分通过增强骨吸收来提高血清钙水平。因此，PTH持续过度作用会因骨吸收增加导致皮质骨丢失。相比之下，间歇性注射PTH制剂主要通过增强骨形成来增加小梁骨。特立帕肽是一种由34个氨基酸组成的肽，对应于PTH的N端部分。在日本，特立帕肽有每日一次和每周一次皮下注射两种剂型。特立帕肽已被证明可预防椎体骨折。此外，每日一次注射特立帕肽还可减少非椎体骨折。然而，关于特立帕肽制剂确切的作用机制仍有几个问题尚未得到解答。
