Nicolini Andrea, Ferrari Paola, Rossi Giuseppe
Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Pisa, Italy.
Unit of Epidemiology and Biostatistics, National Council of Research, Pisa, Italy.
Adv Exp Med Biol. 2015;867:197-225. doi: 10.1007/978-94-017-7215-0_13.
Structural and functional characteristics of mucins and cytokeratins are shortly described. Thereafter, those commonly used in breast cancer as serum tumor markers are considered. First CA15.3, MCA, CA549, CA27.29 mucins and CYFRA21.1, TPA, TPS cytokeratins alone or in association have been examined in different stages and conditions. Then their usefulness in monitoring disease-free breast cancer patients is evaluated. The central role of the established cut-off and critical change, the "early" treatment of recurrent disease and the potential benefit in survival are other issues that have been highlighted and discussed. The successive sections and subsections deal with the monitoring of advanced disease. In them, the current recommendations and the principal findings on using the above mentioned mucins and cytokeratins have been reported. A computer program for interpreting consecutive measurements of serum tumor markers also has been illustrated. The final part of the chapter is devoted to mucins and cytokeratins as markers of circulating and disseminated tumor cells and their usefulness for prognosis.
简要描述了黏蛋白和细胞角蛋白的结构与功能特征。此后，考虑了那些在乳腺癌中常用作血清肿瘤标志物的物质。首先，单独或联合检测了CA15.3、MCA、CA549、CA27.29黏蛋白以及CYFRA21.1、TPA、TPS细胞角蛋白在不同阶段和条件下的情况。然后评估了它们在监测无病乳腺癌患者方面的效用。既定的临界值和关键变化的核心作用、复发性疾病的“早期”治疗以及生存方面的潜在益处是其他已被强调和讨论的问题。后续各节和子节涉及晚期疾病的监测。其中报告了关于使用上述黏蛋白和细胞角蛋白的当前建议和主要发现。还展示了一个用于解释血清肿瘤标志物连续测量结果的计算机程序。本章的最后一部分专门讨论黏蛋白和细胞角蛋白作为循环和播散肿瘤细胞的标志物及其预后效用。
