Wragg R E, Jeste D V
Department of Psychiatry, University of California, San Diego.
Am J Psychiatry. 1989 May;146(5):577-87. doi: 10.1176/ajp.146.5.577.
The authors reviewed 30 studies on Alzheimer's disease to determine the prevalence and phenomenology of affective and psychotic symptoms in patients with this disorder. Depressive and psychotic symptoms occurred in 30%-40% of the Alzheimer's disease patients. Isolated symptoms were two to three times as frequent as diagnosable affective or psychotic disorders. Paranoid delusions were the most common psychotic symptoms reported. Implications of the relationship of psychiatric symptoms to the clinical presentation of Alzheimer's disease, patterns of cognitive dysfunction, clinical management, and areas for future research are discussed.
作者回顾了30项关于阿尔茨海默病的研究，以确定该疾病患者情感和精神症状的患病率及现象学特征。30%-40%的阿尔茨海默病患者出现抑郁和精神症状。孤立症状的出现频率是可诊断的情感或精神障碍的两到三倍。偏执妄想是报告中最常见的精神症状。文中讨论了精神症状与阿尔茨海默病临床表现、认知功能障碍模式、临床管理以及未来研究领域之间关系的意义。
