Mayer Kenneth H, Oldenburg Catherine E, Novak David S, Elsesser Steven A, Krakower Douglas S, Mimiaga Matthew J
The Fenway Institute, Fenway Health, 1340 Boylston Street, Boston, MA, 02215, USA.
Beth Israel Deaconess Medical Center, Boston, MA, USA.
AIDS Behav. 2016 Jul;20(7):1489-98. doi: 10.1007/s10461-015-1237-1.
To date, little data on pre-exposure prophylaxis (PrEP) users outside of the clinical trial setting are available. A repeated cross-sectional survey of one of the largest social and sexual networking websites for men who have sex with men (MSM) in the United States was conducted in August 2013 (Wave 1) and January 2014 (Wave 2). Multivariable logistic regression models were used to assess factors associated with having heard of and having taken post-exposure prophylaxis (PEP) and PrEP in Wave 1 (N = 4043) and Wave 2 (N = 2737) separately. In Wave 1, 147 (3.6 %) and 61 (1.5 %) reported using PEP and PrEP, respectively, compared to 119 (4.4 %) and 62 (2.3 %) in Wave 2. Higher-risk sexual behaviors were associated with having taken PEP and PrEP, and previous PEP use was associated with having taken PrEP. Understanding factors that are associated with early use of PrEP may help inform wider utilization of PrEP by at risk MSM.
迄今为止，几乎没有关于临床试验环境之外的暴露前预防（PrEP）使用者的数据。2013年8月（第1波）和2014年1月（第2波）对美国最大的男男性行为者（MSM）社交和性网络网站之一进行了重复横断面调查。多变量逻辑回归模型分别用于评估在第1波（N = 4043）和第2波（N = 2737）中听说过并使用过暴露后预防（PEP）和PrEP的相关因素。在第1波中，分别有147人（3.6%）和61人（1.5%）报告使用过PEP和PrEP，相比之下，在第2波中分别有119人（4.4%）和62人（2.3%）。高风险性行为与使用PEP和PrEP相关，而先前使用过PEP与使用PrEP相关。了解与早期使用PrEP相关的因素可能有助于为有风险的男男性行为者更广泛地使用PrEP提供信息。
