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火鸡砂囊钙调蛋白15千道尔顿肌动蛋白结合片段的氨基酸序列：与肌营养不良蛋白、原肌球蛋白及肌钙蛋白T的原肌球蛋白结合区域的相似性

Amino acid sequence of a 15 kilodalton actin-binding fragment of turkey gizzard caldesmon: similarity with dystrophin, tropomyosin and the tropomyosin-binding region of troponin T.

作者信息

Leszyk J, Mornet D, Audemard E, Collins J H

机构信息

Department of Biological Chemistry, School of Medicine, University of Maryland, Baltimore 21201.

出版信息

Biochem Biophys Res Commun. 1989 Apr 14;160(1):210-6. doi: 10.1016/0006-291x(89)91642-2.

DOI:10.1016/0006-291x(89)91642-2
PMID:2653315
Abstract

We have determined the amino acid sequence of a 15 kDa actin-binding fragment of turkey gizzard caldesmon. The 96-residue fragment contains 29 acidic and 29 basic residues, and is predicted to have an extended helical conformation stabilized by numerous internal salt bridges. CaD15 bears some resemblance to dystrophin, tropomyosin and several other proteins, but is most strikingly similar to the tropomyosin-binding segment of troponin T.

摘要

我们已经确定了火鸡肌胃钙调蛋白一个15 kDa肌动蛋白结合片段的氨基酸序列。这个96个残基的片段含有29个酸性残基和29个碱性残基，预计具有由众多内部盐桥稳定的延伸螺旋构象。CaD15与肌营养不良蛋白、原肌球蛋白和其他几种蛋白质有一些相似之处，但与肌钙蛋白T的原肌球蛋白结合片段最为相似。

相似文献

1
Amino acid sequence of a 15 kilodalton actin-binding fragment of turkey gizzard caldesmon: similarity with dystrophin, tropomyosin and the tropomyosin-binding region of troponin T.火鸡砂囊钙调蛋白15千道尔顿肌动蛋白结合片段的氨基酸序列：与肌营养不良蛋白、原肌球蛋白及肌钙蛋白T的原肌球蛋白结合区域的相似性
Biochem Biophys Res Commun. 1989 Apr 14;160(1):210-6. doi: 10.1016/0006-291x(89)91642-2.
2
Caldesmon structure and function: sequence analysis of a 35 kilodalton actin- and calmodulin-binding fragment from the C-terminus of the turkey gizzard protein.
Biochem Biophys Res Commun. 1989 May 15;160(3):1371-8. doi: 10.1016/s0006-291x(89)80155-x.
3
Turkey gizzard caldesmon: complete sequence of a C-terminal thrombic fragment that binds actin, tropomyosin and calmodulin.
Protein Seq Data Anal. 1991 Jul;4(1):29-32.
4
35 kDa fragment of h-caldesmon conserves two consensus sequences of the tropomyosin-binding domain in troponin T.
Biochem Biophys Res Commun. 1989 May 30;161(1):38-45. doi: 10.1016/0006-291x(89)91556-8.
5
Characterization of the carboxyl-terminal 10-kDa cyanogen bromide fragment of caldesmon as an actin-calmodulin-binding region.钙调蛋白羧基末端10 kDa溴化氰片段作为肌动蛋白 - 钙调蛋白结合区域的特性研究
J Biol Chem. 1990 Sep 5;265(25):15231-8.
6
Characteristics of the myosin and tropomyosin binding regions of the smooth muscle caldesmon.平滑肌钙调蛋白的肌球蛋白和原肌球蛋白结合区域的特征
Biochem Biophys Res Commun. 1989 May 15;160(3):1316-22. doi: 10.1016/s0006-291x(89)80147-0.
7
Structure-activity studies of the regulatory interaction of the 10 kilodalton C-terminal fragment of caldesmon with actin and the effect of mutation of caldesmon residues 691-696.钙调蛋白10千道尔顿C末端片段与肌动蛋白调节相互作用的构效关系研究及钙调蛋白691 - 696位残基突变的影响
Biochemistry. 1998 Feb 24;37(8):2314-26. doi: 10.1021/bi971727b.
8
Structural study of gizzard caldesmon and its interaction with actin. Binding involves residues of actin also recognised by myosin subfragment 1.砂囊钙调蛋白的结构研究及其与肌动蛋白的相互作用。结合涉及肌动蛋白中也被肌球蛋白亚片段1识别的残基。
Eur J Biochem. 1990 Nov 13;193(3):687-96. doi: 10.1111/j.1432-1033.1990.tb19388.x.
9
Location of smooth-muscle myosin and tropomyosin binding sites in the C-terminal 288 residues of human caldesmon.平滑肌肌球蛋白和原肌球蛋白结合位点在人钙调蛋白C末端288个残基中的定位。
Biochem J. 1995 Dec 1;312 ( Pt 2)(Pt 2):617-25. doi: 10.1042/bj3120617.
10
Epitope mapping of monoclonal antibodies against caldesmon and their effects on the binding of caldesmon to Ca++/calmodulin and to actin or actin-tropomyosin filaments.抗钙调蛋白单克隆抗体的表位作图及其对钙调蛋白与Ca++/钙调素以及与肌动蛋白或肌动蛋白-原肌球蛋白丝结合的影响。
Cell Motil Cytoskeleton. 1991;20(2):95-108. doi: 10.1002/cm.970200203.

引用本文的文献

1
Electron microscopic images suggest both ends of caldesmon interact with actin filaments.电子显微镜图像显示，钙调蛋白的两端均与肌动蛋白丝相互作用。
J Muscle Res Cell Motil. 1993 Feb;14(1):54-64. doi: 10.1007/BF00132180.
2
Studies on secondary structure of caldesmon and its C-terminal fragments.钙调蛋白及其C末端片段的二级结构研究。
Biochem J. 1993 Jul 15;293 ( Pt 2)(Pt 2):363-8. doi: 10.1042/bj2930363.
3
Characterization of a caldesmon fragment that competes with myosin-ATP binding to actin.一种与肌球蛋白 - ATP 结合肌动蛋白相竞争的钙调蛋白片段的特性分析。
Biophys J. 1993 Aug;65(2):892-8. doi: 10.1016/S0006-3495(93)81113-5.
4
Isolated dystrophin molecules as seen by electron microscopy.通过电子显微镜观察到的分离的肌营养不良蛋白分子。
Proc Natl Acad Sci U S A. 1990 Oct;87(20):7851-5. doi: 10.1073/pnas.87.20.7851.
5
The molecular anatomy of caldesmon.钙调蛋白的分子解剖学
Biochem J. 1991 Oct 1;279 ( Pt 1)(Pt 1):1-16. doi: 10.1042/bj2790001.
6
Histological distribution and developmental changes of tropomyosin isoforms in three chicken digestive organs.
Cell Tissue Res. 1992 Sep;269(3):391-401. doi: 10.1007/BF00353894.