CD44表达在儿童肝母细胞瘤中的临床意义

Clinical significance of CD44 expression in children with hepatoblastoma.

作者信息

Cai H-Y, Yu B, Feng Z-C, Qi X, Wei X-J

机构信息

Department of General Surgery, General Hospital of Beijing Military Region, Beijing, China.

Ba Yi Children's Hospital Affiliated Beijing Military General Hospital, No. 5 Nan Men Cang, East District, Beijing, China.

出版信息

Genet Mol Res. 2015 Oct 27;14(4):13203-7. doi: 10.4238/2015.October.26.16.

DOI:10.4238/2015.October.26.16

PMID:26535633

Abstract

The aim of this study was to investigate the expression of CD44 and its clinical significance in children suffering from hepatoblastoma (HB). CD44 expression was detected with immunohistochemistry staining in 30 samples from hepatoblastoma children and 10 normal liver tissue samples from normal children. The data obtained was statistically analyzed using the chi-square test, using the SPSS (v.11.0) software. The rate of CD44 expression was significantly higher (66.7%) in hepatoblastoma tissues than in normal liver tissues (χ(2) = 4.848, P < 0.05). The rate of CD44 expression was significantly higher in children with stage III or IV hepatoblastoma (83.3%) than that in children with stage I and II hepatoblastoma (χ(2) ＝ 5.625, P < 0.05) (41.7%). Therefore, CD44 expression might play an important role in the pathogenesis, progression, and prognosis of HB in children.

摘要

本研究旨在探讨CD44在儿童肝母细胞瘤（HB）中的表达及其临床意义。采用免疫组织化学染色法检测30例肝母细胞瘤患儿样本及10例正常儿童正常肝组织样本中CD44的表达情况。使用SPSS（v.11.0）软件，通过卡方检验对所得数据进行统计学分析。肝母细胞瘤组织中CD44表达率（66.7%）显著高于正常肝组织（χ(2)=4.848，P<0.05）。Ⅲ期或Ⅳ期肝母细胞瘤患儿的CD44表达率（83.3%）显著高于Ⅰ期和Ⅱ期肝母细胞瘤患儿（χ(2)＝5.625，P<0.05）（41.7%）。因此，CD44表达可能在儿童肝母细胞瘤的发病机制、进展及预后中起重要作用。