Bussel B, Roby-Brami A, Yakovleff A, Bennis N
INSERM U 215, Hopital Raymond Poincaré, Garches, France.
Brain Res Bull. 1989 Jan;22(1):53-6. doi: 10.1016/0361-9230(89)90127-5.
We demonstrated previously that electrical stimulation of the Flexor Reflex Afferents (FRA) induces a late flexion reflex with a central conduction time longer than 100 msec. Its latency is prolonged by increasing the intensity or the duration of the stimulation. This late reflex is therefore similar to the late flexion reflex observed in acute spinal cat with DOPA. Some findings suggest that in man the late flexion reflex could be inhibited at a premotoneuronal level by contralateral FRA stimulation. In relation to the late flexion reflex, a late contralateral facilitation of soleus monosynaptic reflex (MSR) was observed. Rhythmical activity was observed in only one patient who had an exceptional form of spinal myoclonus. This myoclonus could be modulated by FRA stimulation. These facts show that the reflex organization in paraplegic patients is similar to the one described in acute spinal cat with DOPA and therefore suggest that a spinal stepping generator could exist in humans.
我们之前证明，电刺激屈肌反射传入神经（FRA）会诱发一种晚期屈肌反射，其中枢传导时间超过100毫秒。通过增加刺激强度或持续时间，其潜伏期会延长。因此，这种晚期反射类似于在急性脊髓猫中用左旋多巴观察到的晚期屈肌反射。一些研究结果表明，在人类中，对侧FRA刺激可能在运动神经元前水平抑制晚期屈肌反射。关于晚期屈肌反射，观察到比目鱼肌单突触反射（MSR）的晚期对侧易化。仅在一名患有特殊形式脊髓肌阵挛的患者中观察到节律性活动。这种肌阵挛可通过FRA刺激进行调节。这些事实表明，截瘫患者的反射组织与用左旋多巴处理的急性脊髓猫中描述的相似，因此表明人类可能存在脊髓步行发生器。
