Rajguru Anirudha, Moulla Alexandra, Ogunremi Adeyemi, Venkatraman Lakshmi, McCluggage W Glenn, Nayar Anitha G
Departments of Pathology (A.R., A.M, A.G.N.) Gynaecology and Obstetrics (A.O.), Princess Royal University Hospital, Orpington, Kent Department of Pathology (L.V., W.G.M.), Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
Int J Gynecol Pathol. 2016 Mar;35(2):123-6. doi: 10.1097/PGP.0000000000000230.
Microglandular adenosis of the breast is an uncommon lesion which can mimic tubular carcinoma. It is composed of small round tubules lined by a single layer of flat or cuboidal epithelial cells, often with eosinophilic colloid-like material within the lumen. The absence of a myoepithelial cell layer and preservation of basement membrane around the tubules are characteristic features. We report the first case of a vulval "neoplasm" in a 60-yr-old woman showing features identical to microglandular adenosis of the breast except for the presence of an unusual chondromyxoid stroma. This case reinforces the analogy between vulval lesions derived from anogenital mammary-like glands and breast lesions and also adds a new entity to the list of lesions arising from these glands.
乳腺微腺性腺病是一种罕见的病变,可酷似小管癌。它由小圆形小管组成,内衬单层扁平或立方形上皮细胞,管腔内常含有嗜酸性胶体样物质。小管周围缺乏肌上皮细胞层且基底膜完整是其特征性表现。我们报告了首例发生在一名60岁女性外阴的“肿瘤”,其表现与乳腺微腺性腺病相同,只是存在不寻常的软骨黏液样间质。该病例强化了源自肛门生殖区乳腺样腺体的外阴病变与乳腺病变之间的相似性,也为这些腺体来源的病变清单增添了一个新的实体。